abstract：BACKGROUND AND OBJECTIVES:Variant RHD genes associated with the weak D phenotype can result in complete or partial D-epitope expression on the red cell. This study examines the genetic classification in Australian blood donors with a weak D phenotype and correlates RHD variants associated with the weak D phenotype agai...

journal_title：Vox sanguinis

authors： McGowan EC,Lopez GH,Knauth CM,Liew YW,Condon JA,Ramadi L,Parsons K,Turner EM,Flower RL,Hyland CA

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Plasma transfusions are a frequent treatment worldwide, but many studies have reported a wide variation in the indications to transfuse. Recently, an international paediatric study also showed wide variation in frequency in the use of plasma transfusions: 25% of the centres transfused plasma t...

journal_title：Vox sanguinis

authors： Karam O,Demaret P,Duhamel A,Shefler A,Spinella PC,Tucci M,Leteurtre S,Stanworth SJ,PlasmaTV investigators.

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:There are no randomized trials comparing intravenous iron to RBC transfusion for the treatment of severe postpartum anaemia. The objectives of this study were to evaluate the feasibility of randomizing women with severe postpartum anaemia secondary to postpartum haemorrhage to RBC transfusion ...

journal_title：Vox sanguinis

authors： Holm C,Thomsen LL,Norgaard A,Langhoff-Roos J

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Fever is described in transfusion-associated circulatory overload (TACO), reflecting either comprehensive haemovigilance or an inflammatory pathobiology (such as congestion-associated atheroma disruptions). METHODS:Hospital haemovigilance data (1/1/2010-31/12/2012) were reviewed for TACO cases (frequency an...

journal_title：Vox sanguinis

authors： Parmar N,Pendergrast J,Lieberman L,Lin Y,Callum J,Cserti-Gazdewich C

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The objective of the study was to investigate the splanchnic blood flow velocity and oximetry response to blood transfusion in preterm infants according to postnatal age. MATERIALS AND METHODS:Preterm infants receiving blood transfusion were recruited to three groups: 1-7 (group 1; n = 20), 8-...

journal_title：Vox sanguinis

authors： Banerjee J,Leung TS,Aladangady N

更新日期：2016-11-01 00:00:00

abstract：:This study describes a new method for comparison of fluid motion and associated shear forces with various modes of platelet agitation. Fluid motion generated by flatbed, tumbler-type and circular platelet agitators was investigated. Trajectory tracings of polyethylene beads suspended inside platelet storage bags were ...

journal_title：Vox sanguinis

authors： Torres R,Tormey CA,Stack G

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Our post-thaw cell recovery rates differed substantially in interlaboratory comparisons of identical samples, potentially due to different temperatures during cell staining. MATERIALS AND METHODS:Viable CD34(+) cells and leucocyte (WBC) subtypes were quantified by multiparameter single-platfo...

journal_title：Vox sanguinis

authors： Fritsch G,Frank N,Dmytrus J,Frech C,Pichler H,Witt V,Geyeregger R,Scharner D,Trbojevic D,Zipperer E,Printz D,Worel N

更新日期：2016-08-01 00:00:00

abstract：:A retrospective analysis was conducted on 20 D(-) liver transplant (LT) recipients transfused with D(+) RBCs perioperatively and screened for RBC antibodies between 2 and 6 months later. None developed anti-D detectable by the indirect antiglobulin test. Two patients produced weak anti-D that reacted only with papain-...

journal_title：Vox sanguinis

authors： Burin des Roziers N,Ibanez C,Samuel D,Francoz C,Idri S,François A,Mortelecque R,Bierling P,Pirenne F

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Apheresis platelet concentrates sometimes contain persistent aggregates (PA). Because apheresis involves extracorporeal circulation, we hypothesized that interactions between GPIbα and von Willebrand factor (VWF) underlie their origin. MATERIALS AND METHODS:Platelets in donations with PA were...

journal_title：Vox sanguinis

authors： Feys HB,Van Aelst B,Devloo R,Vandekerckhove P,Compernolle V

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Allergic transfusion reactions (ATRs) and febrile non-haemolytic transfusion reactions (FNHTRs) are the two major types of transfusion-related adverse reactions (TRARs). Although prestorage leucocyte reduction and diversion of the first aliquot of blood (LR/D) could reduce FNHTRs and bacterial...

journal_title：Vox sanguinis

authors： Yanagisawa R,Shimodaira S,Sakashita K,Hidaka Y,Kojima S,Nishijima F,Hidaka E,Shiohara M,Nakamura T

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Ross River virus (RRV) is an enveloped, RNA alphavirus in the same antigenic group as chikungunya virus. Australia records an annual average of 5000 laboratory-confirmed RRV infections. While RRV is currently geographically restricted to the Western Pacific, the capacity of arboviruses for rap...

journal_title：Vox sanguinis

authors： Seed CR,Hoad VC,Faddy HM,Kiely P,Keller AJ,Pink J

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:New CD36 mutations are constantly being identified, although no study has specifically targeted a Taiwanese population. CD36 deficiency can result in dyslipid state and slow clearance of chylomicron. This could be linked to more frequent lipemic donations. STUDY DESIGN AND METHODS:We used flow cytometric me...

journal_title：Vox sanguinis

authors： Lo SC,Lin KH,Hsieh HH,Lin DT,Hu CY

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Hepcidin is the main hormone that regulates iron balance. Its lowering favours digestive iron absorption in cases of iron deficiency or enhanced erythropoiesis. The careful dosage of this small peptide promises new diagnostic and therapeutic strategies. Its measurement is progressively being v...

journal_title：Vox sanguinis

authors： Waldvogel S,Rochat B,Peduzzi D,Vaucher P,Tissot JD,Favrat B

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The molecular basis of the weak D phenotype has been investigated for many years, and more than 80 different alleles producing weak D phenotypes have been identified. Most alleles producing weak D phenotypes have a single missense mutation in exons corresponding to a transmembrane domain of th...

journal_title：Vox sanguinis

authors： Ogasawara K,Sasaki K,Isa K,Tsuneyama H,Uchikawa M,Satake M,Tadokoro K

更新日期：2016-02-01 00:00:00

abstract：:Ocular chronic GVHD is efficaciously treated with autologous platelet-derived eye drops. We investigated the cytokine content of eye drops produced using a non-gelified lysate obtained from autologous platelet-rich plasma in six patients with ocular GVHD. In both the responding (n = 4) and the resistant (n = 2) patien...

journal_title：Vox sanguinis

authors： Valentini CG,Nuzzolo ER,Orlando N,Metafuni E,Bianchi M,Chiusolo P,Zini G,Teofili L

更新日期：2016-02-01 00:00:00

abstract：:Recent investigation of transcriptional regulation of the ABO genes has identified a candidate erythroid cell-specific regulatory element, named the +5·8-kb site, in the first intron of ABO. Six haplotypes of the site have been reported previously. The present genetic population study demonstrated that each haplotype ...

journal_title：Vox sanguinis

authors： Nakajima T,Sano R,Takahashi Y,Watanabe K,Kubo R,Kobayashi M,Takahashi K,Takeshita H,Kominato Y

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Transfusion support for immune-mediated platelet refractoriness (PR) is clinically challenging, technically laborious and costly. The development of 'EpHLA/EpVix software' has been used successfully to select kidney donors. Here, we sought to evaluate this new software as a tool for platelet v...

journal_title：Vox sanguinis

authors： Bub CB,Gonçalez AC,Barjas-Castro ML,Sousa LC,do Monte SJ,Castro V

更新日期：2016-01-01 00:00:00

abstract：:Hepatitis E virus (HEV)-positive plasma donations, identified by a plasma mini-pool screening approach, were analysed using serological methods for the presence of anti-HEV IgM and IgG. Avidity testing was performed on the IgG-reactive donations. Anti-HEV IgG with high avidity was observed in two donors together with ...

journal_title：Vox sanguinis

authors： Baylis SA,Crossan C,Corman VM,Blümel J,Scobie L,Dalton HR

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:One of the challenges surrounding blood component administration is the determination of an appropriate rate of infusion. There are very few evidence-based guidelines available to guide healthcare providers looking for a 'standard' infusion rate for red blood cells (RBCs), plasma or platelets ...

journal_title：Vox sanguinis

authors： Gehrie EA,Hendrickson JE,Tormey CA

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Regulatory T cells (Tregs) and other T-cell subsets are of importance in the setting of autologous and allogeneic stem cell transplantations. We conducted a study to assess the content of peripheral blood stem cell concentrates and related apheresis parameters in the autologous and allogeneic ...

journal_title：Vox sanguinis

authors： Strobel J,Moellmer I,Zingsem J,Hauck-Dlimi B,Eckstein R,Strasser E

更新日期：2015-11-01 00:00:00

abstract：:Haemolytic Disease of the Fetus and Newborn (HDFN) is caused by maternal alloimmunization against red blood cell antigens. In severe cases, HDFN may lead to fetal anaemia with a risk for fetal death and to severe forms of neonatal hyperbilirubinaemia with a risk for kernicterus. Most severe cases are caused by anti-D,...

journal_title：Vox sanguinis

authors： de Haas M,Thurik FF,Koelewijn JM,van der Schoot CE

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The risk of transfusion-transmitted human T-lymphotropic virus type 1 infection (TT-HTLV-1) after prestorage leucocyte reduction (LR) remains unknown, as the proviral load in the blood component that would cause TT-HTLV-1 is undetermined. On the basis of the distribution of HTLV-1 proviral loa...

journal_title：Vox sanguinis

authors： Sobata R,Matsumoto C,Uchida S,Suzuki Y,Satake M,Tadokoro K

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Aggregates often appear during apheresis. Sometimes, these persist throughout storage, causing product wastage. This study assessed product quality of apheresis concentrates containing persistent aggregates (PA) and aimed to identify the factors that contribute to their formation. METHODS:Donation (n = 180)...

journal_title：Vox sanguinis

authors： Feys HB,Coene J,Devloo R,Van Aelst B,Pottel H,Vandekerckhove P,Compernolle V

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Miltenberger subtype III (Mi.III, GP.Mur) is one of the most important red cell phenotypes in the fields of transfusion in South-East Asia. GP.Mur is believed to evolve from homologous gene recombination events between glycophorin A (GYPA) and glycophorin B (GYPB). GYP.Mur differs from GYPB in...

journal_title：Vox sanguinis

authors： Hsu K,Yao CC,Lin YC,Chang CL,Lee TY

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Photochemical treatment (PCT) of platelet concentrates using photosensitizers and ultraviolet light illumination reduces the proliferation potential of pathogens by damaging biomolecules. MATERIALS AND METHODS:The impact of riboflavin (RF-PRT)- and amotosalen (AS-PCT)-based pathogen inactivation on platelet...

journal_title：Vox sanguinis

authors： Van Aelst B,Feys HB,Devloo R,Vanhoorelbeke K,Vandekerckhove P,Compernolle V

更新日期：2015-05-01 00:00:00

abstract：:The Am and Bm phenotypes are characterized by weak expression of the A or B antigens, respectively, by red blood cells with a normal expression by the saliva of secretors. Deletion of the regulatory element in the first intron of the ABO gene and disruption of the GATA motif in the element were found to be responsible...

journal_title：Vox sanguinis

authors： Oda A,Isa K,Ogasawara K,Kameyama K,Okuda K,Hirashima M,Ishii H,Kimura K,Matsukura H,Hirayama F,Kawa K

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Recent studies suggest that transfusion of old red blood cell (RBC)s, mainly those close to the 42-day maximum shelf life (MSL), is associated with increased morbi-mortality. Although there is no formal proof supporting a causal relationship, the precautionary principle asks for corrective inte...

journal_title：Vox sanguinis

authors： Grasas A,Pereira A,Bosch MA,Ortiz P,Puig L

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Previous studies with p38MAPK inhibitors at room temperature demonstrated that they improve a large number of platelet storage parameters, but cannot substantially inhibit p38MAPK activation nor protect against widespread decrements in platelet quality parameters during 4 °C storage. In this s...

journal_title：Vox sanguinis

authors： Wagner SJ,Skripchenko A,Seetharaman S,Kurtz J

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Repeated blood donation produces iron deficiency. Changes in dietary iron intake do not prevent donation-induced iron deficiency. Prolonging the interdonation interval or using oral iron supplements can mitigate donation-induced iron deficiency. The most effective operational methods for reduc...

journal_title：Vox sanguinis

authors： Bialkowski W,Bryant BJ,Schlumpf KS,Wright DJ,Birch R,Kiss JE,D'Andrea P,Cable RG,Spencer BR,Vij V,Mast AE

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The last two decades have seen major developments in genotyping assays to facilitate the procurement of red blood cell units to alloimmunized patients. To make genotyping faster, simpler and less costly, a nanotechnology approach based on metal/silica fluorescent nanoparticles and a polymer-ba...

journal_title：Vox sanguinis

authors： Brouard D,Ratelle O,Perreault J,Boudreau D,St-Louis M

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Donor plasmapheresis involves the removal of a weight-adjusted volume of plasma and the return of cellular components to the donor. Although plasma volume generally returns to normal, some residual effect on vital signs may be possible. This analysis was performed to determine the possible eff...

journal_title：Vox sanguinis

authors： Rosa-Bray M,Wisdom C,Marier JF,Mouksassi MS,Wada S

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Plasma exchange (PE) and immunoadsorption with the Immusorba TR-350 column (IA) are used to remove autoantibodies from plasma in acute neurological autoimmune disorders. The impact of IA on coagulation and on low molecular weight heparin (LMWH) levels in comparison with PE was investigated. P...

journal_title：Vox sanguinis

authors： Koessler J,Kobsar A,Kuhn S,Koessler A,Yilmaz P,Weinig E,Putz E,Boeck M,Klinker E

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:An Australian Caucasian blood donor consistently presented a serology profile for the Duffy blood group as Fy(a+b+) with Fy(a) antigen expression weaker than other examples of Fy(a+b+) red cells. Molecular typing studies were performed to investigate the reason for the observed serology profil...

journal_title：Vox sanguinis

authors： Lopez GH,Condon JA,Wilson B,Martin JR,Liew YW,Flower RL,Hyland CA

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Transfusion is associated with a risk of infection and alloimmunization. Pathogen reduction using riboflavin and UV light (Mirasol treatment) inactivates pathogens and leucocytes. With increasing adoption of the technology in clinical use, regulatory agencies have recommended the introduction ...

journal_title：Vox sanguinis

authors： Bakkour S,Chafets DM,Wen L,van der Meer PF,Mundt JM,Marschner S,Goodrich RP,Busch MP,Lee TH

更新日期：2014-11-01 00:00:00

abstract：:One of the most controversial policies in blood transfusion worldwide is the permanent deferral from donating blood of men with sexual contacts to other men (MSM). This policy was implemented for safety reasons as sex between men is known to be a high risk factor for acquiring severe infectious diseases transmissible ...

journal_title：Vox sanguinis

authors： Offergeld R,Kamp C,Heiden M,Norda R,Behr-Gross ME

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Gene conversion events between GYPA and GYPB or GYPA and GYPE are facilitated by the close chromosomal proximity and high degree of sequence homology and can lead to the formation of GP hybrid genes. Discrepant results between blood group genotyping and haemagglutination in 22 random blood don...

journal_title：Vox sanguinis

authors： Polin H,Danzer M,Reiter A,Brisner M,Gaszner W,Weinberger J,Gabriel C

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Inaccuracy of fingerstick haemoglobin compromises donor's health and losses blood donations. We evaluated the benefit of double haemoglobin screening with HemoCue. STUDY DESIGN AND METHODS:Blood donors underwent fingerstick screening by HemoCue and were driven for donation if capillary haemog...

journal_title：Vox sanguinis

authors： Gómez-Simón A,Plaza EM,Torregrosa JM,Ferrer-Marín F,Sánchez-Guiu I,Vicente V,Lozano ML,Rivera J

更新日期：2014-11-01 00:00:00

abstract：:Present platelet storage media often designated platelet additive solutions (PAS) basically contain acetate, citrate and phosphate and recently also potassium and magnesium. However, there seems to be an increasing interest in developing PASs that can be used also after further reduction of residual plasma content bel...

journal_title：Vox sanguinis

authors： Gulliksson H

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Parvovirus B19 (B19V) DNA seems to persist in the plasma of B19V-infected blood donors. The relevance of this for recipients of single-donor blood components is yet unclear. MATERIAL AND METHODS:We studied serial archive and follow-up samples from 75 B19V-infected blood donors to obtain more ...

journal_title：Vox sanguinis

authors： Juhl D,Görg S,Hennig H

更新日期：2014-10-01 00:00:00

abstract：:Bacterial contamination of platelet concentrates poses a major post-transfusion infectious risk. This study was aimed at evaluating the efficacy of the BacTx(®) assay (Immunetics Inc.) for bacterial detection in leucocyte-reduced buffy coat platelet pools and for its sensitivity in detecting clinical isolates, includi...

journal_title：Vox sanguinis

authors： Ramirez-Arcos S,Kou Y,Perkins H

更新日期：2014-08-01 00:00:00